Southampton boss Ronald Koeman says Morgan Schneiderlin is not in the right frame of mind to play against Bayer Leverkusen.
The French international was heavily linked with a move to Tottenham Hotspur a couple of weeks ago and was upset when Saints chairman Ralph Krueger insisted that the player would not be moving anywhere.
Schneiderlin spent two days training separately this week, but Saints are prepared to remain firm that he will not be leaving for Tottenham.
“The situation is difficult, the player makes it difficult,” Saints boss Ronald Koeman told the press.
“I spoke to him with our chairman and the situation has not changed – we don’t sell Schneiderlin and he has to accept that.
“Tomorrow he is not in the squad. He said he is not physically and, even more, mentally prepared for tomorrow.
“On one side I can understand that. We told him to take the weekend off and think about the situation.”
Koeman added: “He will continue as a football player of Southampton. Now it is up to him.”