Tottenham are suffering from injuries at the moment, with a number of first team stars on the side lines, and the fixtures piling up fast.
The 4-2 loss to Barcelona would have taken it out of the boys on Wednesday night, but there is little room for rotation as the squad thins and thins.
The likes of Christian Eriksen, Jan Vertonghen, Mousa Dembele, Dele Alli, Serge Aurier and Luke Amos are all out injured.
Michel Vorm and Hugo Lloris are now fit and in training.
We believe that Pochettino will still want to rotate his full-backs after a testing game mid week, meaning that Rose and Walker-Peters come into the side.
The centre backs are likely to stay the same, with Dier replacing Wanyama in midfield.
The front four are unlikely to change at all, mainly due to a lack of other options on the bench.
What we could see is Pochettino making the most out of a bad situation and giving some of the academy youngsters like Oliver Skipp a run out towards the end of the game.
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