Peter Crouch comes in for Robbie Keane in the only change to the first team from Saturday.
Roman Pavlyuchenko is restored to the bench, but David Bentley is left out of the 18 again.
Tottenham: Gomes, Corluka, Dawson, Bassong, Assou-Ekotto, Lennon, Huddlestone, Palacios, Kranjcar, Crouch, Defoe.
Subs: Alnwick, Hutton, Bale, Jenas, Pavlyuchenko, Keane, Modric.
Manchester City: Given, Richards, Onouha, Toure, Sylvinho, Ireland, De Jong, Barry, Tevez, Adebayor, Robinho.
Subs: Taylor, Zabaleta, Santa Cruz, Petrov, Benjani, Kompany, Weiss.
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